| 猪伪狂犬病病毒新流行株主要糖蛋白的分子特征分析 |
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| 引用本文： | 向柯宇,潘慧,吉艺宽,王雨,张宝石,罗永文,琚春梅.猪伪狂犬病病毒新流行株主要糖蛋白的分子特征分析[J].华南农业大学学报,2016,37(3):23-28. |
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| 作者姓名： | 向柯宇 潘慧 吉艺宽 王雨 张宝石 罗永文 琚春梅 |
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| 作者单位： | 华南农业大学兽医学院/广东省动物源性人兽共患病预防与控制重点实验室,广东广州,510642 |
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| 基金项目： | 国家自然科学基金（31001074） |
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| 摘 要： | 【目的】进一步了解猪伪狂犬病毒新流行株的遗传特征。【方法】对从安徽某猪场分离的1株猪伪狂犬病病毒(PRV)AH株进行遗传进化分析及主要糖蛋白gB、gC、gD、gE的序列分析。【结果】PRV AH株与国内2011年以来的流行毒株非常相似,但与Bartha株及其他国外毒株遗传关系较远;国内流行毒株与Bartha株及其他国外毒株相比,其主要糖蛋白均存在明显的连续氨基酸的缺失和插入,且部分突变位点位于这些糖蛋白的重要功能区。【结论】从分子水平上解析了PRV新流行株与疫苗株Bartha株的遗传差异,为进一步深入研究Bartha株疫苗免疫失败的原因提供了理论依据。
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| 关 键 词： | 伪狂犬病病毒 新流行株 糖蛋白 分子特征 |
| 收稿时间： | 2015/9/11 0:00:00 |
Molecular characteristics of major glycoproteins of the novel pseudorabies virus causing a severe epidemic in China |
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| XIANG Keyu,PAN Hui,JI Yikuan,WANG Yu,ZHANG Baoshi,LUO Yongwen and JU Chunmei.Molecular characteristics of major glycoproteins of the novel pseudorabies virus causing a severe epidemic in China[J].Journal of South China Agricultural University,2016,37(3):23-28. |
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| Authors: | XIANG Keyu PAN Hui JI Yikuan WANG Yu ZHANG Baoshi LUO Yongwen and JU Chunmei |
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| Abstract: | Objective] In order to study the genetic characteristics of the novel epidemic pseudorabies vi-rus ( PRV) .Method]A PRV strain named PRV AH was isolated from a pig farm in Anhui Province , the phylogenetic tree was constructed and the glycoproteins gB ,gC,gD and gE of this strain were analyzed .Result] PRV AH was very similar to an epidemic strain which had caused a severe PRV outbreak in China since 2011 , but was distantly related to Bartha or other foreign strains .Compared with Bartha and other foreign strains , all PRV strains in China had obvious deletions and insertions of continuous amino acids in the glycoproteins , and some mutations were found in the critical functional regions of the glyco-proteins .Conclusion ]This study analyzes the genetic differences between the novel epidemic PRV strain and Bartha strain at the molecular level , which provides a theoretical basis for further clarification of the immunization failure of Bartha-K61 vaccine . |
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| Keywords: | pseudorabies virus novel epidemic strain glycoprotein molecular characteristics |
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