Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk |
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| Authors: | Abtahian Farhad Guerriero Anastasia Sebzda Eric Lu Min-Min Zhou Rong Mocsai Attila Myers Erin E Huang Bin Jackson David G Ferrari Victor A Tybulewicz Victor Lowell Clifford A Lepore John J Koretzky Gary A Kahn Mark L |
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| Institution: | Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. |
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| Abstract: | Lymphatic vessels develop from specialized endothelial cells in preexisting blood vessels, but the molecular signals that regulate this separation are unknown. Here we identify a failure to separate emerging lymphatic vessels from blood vessels in mice lacking the hematopoietic signaling protein SLP-76 or Syk. Blood-lymphatic connections lead to embryonic hemorrhage and arteriovenous shunting. Expression of slp-76 could not be detected in endothelial cells, and blood-filled lymphatics also arose in wild-type mice reconstituted with SLP-76-deficient bone marrow. These studies reveal a hematopoietic signaling pathway required for separation of the two major vascular networks in mammals. |
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