| 非洲猪瘟疫苗研制方向及进展 |
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| 引用本文： | 张振兴,曾毅,宋建领.非洲猪瘟疫苗研制方向及进展[J].中国动物检疫,2022,39(3):61-64. |
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| 作者姓名： | 张振兴 曾毅 宋建领 |
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| 作者单位： | 云南省畜牧兽医科学院;水富市两碗镇人民政府 |
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| 基金项目： | 云南省重大科技专项计划项目（202102AE090039）；国家重点研发计划项目（2018YFC0840405）；畜禽种质创新及标准化养殖技术推广专项（云农财〔2021〕1号） |
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| 摘 要： | 非洲猪瘟(African swine fever,ASF)给全球养殖业造成了巨大的威胁和挑战.非洲猪瘟病毒(African swine fever virus,ASFV)具有比寻常病毒更加巨大的基因组、迅速的变异能力和更加复杂多变的免疫逃逸机制,目前市场上仍无有效预防疫苗.科研人员几十年来,从灭活疫苗、减毒活疫苗、亚单...
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| 关 键 词： | 非洲猪瘟 疫苗研发 疫苗种类 |
Research Direction and Progress of African Swine Fever Virus Vaccines |
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| Zhang Zhenxing,Zeng Yi,Song Jianling.Research Direction and Progress of African Swine Fever Virus Vaccines[J].China Journal Of Animal Quarantine,2022,39(3):61-64. |
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| Authors: | Zhang Zhenxing Zeng Yi Song Jianling |
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| Institution: | (Yunnan Academy of Animal Husbandry and Veterinary Sciences,Yunnan Key Laboratory of Tropical and Subtropical Animal Virus Diseases,Kunming,Yunnan 650224,China;Liangwan Township People's Government,Shuifu,Yunnan 657803,China) |
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| Abstract: | African swine fever(ASF)has posed a great threat and challenge to global aquaculture industry.However,no effective vaccines of African swine fever virus(ASFV)have been available in the market,due to its larger genome,rapid mutation ability and more complex and changeable immune escape mechanism,compared to common viruses.The vaccines have been continuously developed by researchers from the aspects of inactivated vaccine,live attenuated vaccine,subunit vaccine,DNA vaccine and virus vector vaccine.Specifically,the inactivated vaccines is relatively safe,but provides relatively low level of protection;DNA vaccine could induce cellular and humoral immune response,but fails to protect pigs;virus vector vaccine may provide ideal immune protection only when the immunogen gene of ASFV is accurately located;and live attenuated vaccine could provide homologous protection as an ideal way to develop ASFV vaccines at present,but is accompanied by great potential bio-safety hazards.In the paper,the research progress and difficulties related to ASFV vaccine development in different directions were reviewed,with a view to providing new awareness and direction for the area. |
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| Keywords: | ASF research and development of vaccine vaccine type |
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