| 精子趋化性与嗅觉受体基因表达关系研究进展 |
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| 引用本文： | 贾芳,孙子龙,申进军,边疆,王俊东.精子趋化性与嗅觉受体基因表达关系研究进展[J].动物医学进展,2012(2):79-82. |
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| 作者姓名： | 贾芳 孙子龙 申进军 边疆 王俊东 |
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| 作者单位： | 山西农业大学动物科技学院;美国纽约州立大学口腔生物学院 |
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| 基金项目： | 国家自然基金项目(31072180) |
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| 摘 要： | 趋化性作为评价精子健康的一项新的指标,已经逐渐得到认可.20世纪60年代,Miller首次在水生无脊椎动物(海胆、珊瑚虫等)中证实了精子趋化性的存在.研究显示,一些嗅觉受体(OR)基因,如hOR17-4在人鼻子和睾丸中同时存在,并且这种表达与精子的趋化性有关.OR基因的活化可导致胞内Ga2+浓度的升高,进而引起精子的超...
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| 关 键 词： | 精子趋化性 嗅觉受体 不育 |
Progress on Association Between Spermatozoa Chemiotaxis and Expression of Olfactory Receptor Genes |
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| JIA Fang,SUN Zi-long,SHEN Jin-jun,BIAN Jiang,WANG Jun-dong.Progress on Association Between Spermatozoa Chemiotaxis and Expression of Olfactory Receptor Genes[J].Progress In Veterinary Medicine,2012(2):79-82. |
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| Authors: | JIA Fang SUN Zi-long SHEN Jin-jun BIAN Jiang WANG Jun-dong |
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| Institution: | 1 (1.College of Animal Science and Technology,Shanxi Agricultural University,Taigu,Shanxi,030801,China; 2.Department of Oral Biology,State University of New York at Buffalo,Buffalo,NY,14214,USA) |
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| Abstract: | Spermatozoa chemiotaxis has been considered as one of the indexs to evaluate the quality of semen.The spermatozoa chemiotaxis of invertebrate was first confirmed by Miller in 1960s,which showed that olfactory receptor genes are both expressed in testis and mature sperm in mammal.Some research results showed that olfactory receptor(OR),such as hOR17-4 was both in nose and spermary.And spermatozoa chemiotaxis is considered to be related to this expression.Activition of OR can induce the increase of Ga2+ concentration in sperm,which lead to spermatozoa chemiotaxis and is helpful to fertilization.However,the association between spermatozoa chemiotaxis and olfactory receptor genes is on primary groung and is still for future study: Olfactory receptor gense have contribution to the fertilization and could be one way of sperm selective-those sperm who have the expression of olfactory receptor genes can meet with the ovum and successfully fertilization. |
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| Keywords: | spermatoza chemiotaxis olfactory receptor infertility |
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