Evidence that Frescon-induced contractures in Lymnaea stagnalis muscles do not depend on intracellular calcium stores: A comparison with caffeine action |
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Authors: | BL Brezden DR Gardner |
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Institution: | Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada |
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Abstract: | The action of the molluscicide Frescon, which induces contractures in smooth and cross-striated muscles of the freshwater snail Lymnaea stagnalis, was compared with the action of caffeine. The results indicate that the latter agent promotes contractions in Lymnaea muscles by releasing Ca2+ from intracellular stores. Such a release could not be attributed to the action of Frescon. Furthermore, the molluscicide did not appear to alter muscle function at the level of the contractile apparatus as it did not affect the time course of caffeine-induced contractions. These results favor the hypothesis that Frescon increases sarcolemmal Ca2+ permeability. |
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