The mode of action and neurotoxicity of mirex,chlordecone, and four hydrogenated mirex analogs |
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| Authors: | JR Bloomquist DL Shankland |
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| Institution: | Department of Entomology, Mississippi Agricultural and Forestry Experiment Station, Mississippi State University, Mississippi State, Mississippi 39762 USA |
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| Abstract: | The toxicity and neurological effects of mirex, chlordecone, and four hydrogenated mirex analogs were evaluated on the American cockroach. The severity of poisoning symptoms correlated with the ability of each compound to increase spontaneous activity and prolong synaptic afterdischarge in ganglia of the ventral nerve cord. Afterdischarge across the metathoracic ganglion was consistent with a characteristic wing splaying symptom in mirex-poisoned cockroaches. The actions of hemicholinium-3 and nicotine on nerve cords from mirex-poisoned cockroaches are described and are consistent with a hypothesis that the increased spontaneous activity and afterdischarge are the result of enhanced transmitter release in ganglia of poisoned animals. |
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| Keywords: | Present address: Division of Toxicology and Physiology Department of Entomology University of California Riverside Calif 92521 To whom correspondence and reprint requests should be addressed |
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