Difference in the picrotoxinin receptor between the cyclodiene-resistant and susceptible strains of the german cockroach |
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| Authors: | AA Kadous SM Ghiasuddin F Matsumura JG Scott K Tanaka |
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| Institution: | Pesticide Research Center, Michigan State University, East Lansing, Michigan 48824 USA |
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| Abstract: | As a result of toxicity tests, it was established that all cyclodiene-resistant strains of the German cockroach are also resistant to picrotoxinin, a plant-origin neurotoxicant. Two of the cockroach strains which exhibit a distinct cross-resistance pattern to picrotoxinin (i.e., LPP and FRP) are the ones that have been purified genetically by backcrossing against the susceptible (CSMA) strain. This cross-resistance pattern appears to be specific to picrotoxinin and does not extend to other neuroexcitants such as bicuculline, beta-bungarotoxin, and DDT. The nervous system of the resistant cockroach was found to be less sensitive to picrotoxinin. Furthermore, it was determined that nerve components from the resistant cockroaches have significantly lower binding capacity to 3H]α-dihydropicrotoxinin. The most likely explanation for the above phenomenon is that these cockroaches have developed the cyclodiene resistance by altering the nerve receptor for picrotoxinin. |
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| Keywords: | To whom correspondence and requests for reprints should be addressed |
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