Amino Alcohols from the Ascidian Pseudodistoma sp |
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| Authors: | Tae Hyung Won Minjung You So-Hyoung Lee Boon Jo Rho Dong-Chan Oh Ki-Bong Oh Jongheon Shin |
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| Institution: | 1.Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea; E-Mails: (T.H.W.); (M.Y.); (D.-C.O.);2.Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea; E-Mail: ;3.Department of Biological Science, College of Life Science, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun, Seoul 120-750, Korea; E-Mail: |
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| Abstract: | Seven new amino alcohol compounds, pseudoaminols A–G (1–7), were isolated from the ascidian Pseudodistoma sp. collected off the coast of Chuja-do, Korea. Structures of these new compounds were determined by analysis of the spectroscopic data and from chemical conversion. The presence of an N-carboxymethyl group in two of the new compounds (6 and 7) is unprecedented among amino alcohols. Several of these compounds exhibited moderate antimicrobial activity and cytotoxicity, as well as weak inhibitory activity toward Na+/K+-ATPase. |
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| Keywords: | amino alcohols pseudoaminols Pseudodistoma sp stereochemistry bioactivities |
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