Dissociation and phosphorylation constants for the inhibition of acetylcholinesterase by a series of novel O-ethyl O-phenyl S-n-propyl phosphorothioates |
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Authors: | Geoffrey J Hart Richard D OBrien |
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Institution: | Section of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853 USA |
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Abstract: | The phosphorylation, dissociation, and bimolecular reaction constants were determined for several members of a series of substituted O-ethyl O-phenyl S-n-propyl phosphorothioates in the presence of substrate. The data obtained are discussed in relation to electronegativity of substituents and in vivo toxicity. |
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