Environmental degradation of the insect growth regulator methoprene. IX. Metabolism by bluegill fish |
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| Authors: | Gary B Quistad David A Schooley Luana E Staiger B John Bergot Bevier H Sleight Kenneth J Macek |
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| Institution: | Zoecon Corporation Research Laboratory, 975 California Avenue, Palo Alto, California 94304 USA |
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| Abstract: | The accumulation, persistence, and metabolism and/or elimination of methoprene (isopropyl (2E, 4E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate) was examined for bluegill sunfish (Lepomis macrochirus) contained in a dynamic flow-through system and a model aquatic ecosystem. The fish in the dynamic flow-through system acquired moderate residues of largely unmetabolized methoprene when continuously exposed to about 30 times anticipated environmental levels of methoprene, but residues were rapidly eliminated (93–95%) within 2 weeks when fish were transferred to flowing uncontaminated water. When bluegill were treated with methoprene in a model aquatic ecosystem, fish showed a highly misleading accumulation of 14C residues since residual radioactivity was found almost exclusively in radiolabeled natural products, including cholesterol, free fatty acids, glycerides, and protein. Less than 0.1% of the total radioactivity in fish could be attributed to unmetabolized methoprene or its primary metabolites; thus, simple radioassay procedures in ecosystem studies can be severely compromised unless coupled with more sophisticated analytical techniques. |
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