Pharmacokinetics following intravenous administration and pharmacodynamics of cefquinome in buffalo calves |
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| Authors: | Venkatathalam Dinakaran Vinod Kumar Dumka Bibhuti Ranjan Ramalingam Balaje Pritam Kaur Sidhu |
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| Institution: | 1. Department of Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, 141004, India
2. Animal Disease Research Center, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, 141004, India
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| Abstract: | Disposition following single intravenous injection (2 mg/kg) and pharmacodynamics of cefquinome were investigated in buffalo calves 6–8 months of age. Drug levels in plasma were estimated by high-performance liquid chromatography. The plasma concentration–time profile following intravenous administration was best described by a two-compartment open model. Rapid distribution of cefquinome was evident from the short distribution half-life (t ½α ?=?0.36?±?0.01 h), and small apparent volume of distribution (Vdarea?=?0.31?±?0.008 L/kg) indicated limited drug distribution in buffalo calves. The values of area under plasma concentration–time curve, elimination half-life (t ½β ), total body clearance (ClB), and mean residence time were 32.9?±?0.56 μg·h/mL, 3.56?±?0.05 h, 60.9?±?1.09 mL/h/kg, and 4.24?±?0.09 h, respectively. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration of cefquinome were 0.035–0.07 and 0.05–0.09 μg/mL, respectively. A single intravenous injection of 2 mg/kg may be effective to maintain the MIC up to 12 h in buffalo calves against the pathogens for which cefquinome is indicated. |
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