| 内毒素对山羊红细胞膜ATPase活性的影响及654—2的保护效应 |
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| 引用本文： | 高洪,唐兆新.内毒素对山羊红细胞膜ATPase活性的影响及654—2的保护效应[J].畜牧兽医学报,1999,30(3):279-283. |
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| 作者姓名： | 高洪 唐兆新 |
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| 作者单位： | 南京农业大学动物医学院 |
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| 基金项目： | 云南省应用基础研究基金,中国博士后科学研究基金,国家自然科学基金 |
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| 摘 要： | 通过静脉注射的方法研究了大肠杆菌仙毒素对山羊红细胞膜损伤的膜泵分子活性的变化及６５４－２（山莨菪碱）的保护效应。结果表明，ＥＴ处理组在１ｈ，３ｈ红细胞膜Ｎａ＾＋－Ｋ＾＋ＡＴＰａｓｅ（腺苷三磷酸酶，简称ＡＴＰ酶），Ｃａ＾２＋，Ｍｇ＾２＋－ＡＴＰａｓｅ活性均高于对照组，５ｈ有下降趋势并一直持续到９ｈ。
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| 关 键 词： | 内毒素 山莨菪碱 ATP酶 红细胞膜 山羊 ET休克 |
EFFECTSOFENDOTOXINONATPaseACTIVITIESOFERYTHROCYTEMEMBRANEANDPROTECTIONOFANISODAMINEINGOATS |
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| Author GaoHong,TangZhaoxin,ChenWanfang.EFFECTSOFENDOTOXINONATPaseACTIVITIESOFERYTHROCYTEMEMBRANEANDPROTECTIONOFANISODAMINEINGOATS[J].Acta Veterinaria et Zootechnica Sinica,1999,30(3):279-283. |
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| Authors: | Author GaoHong TangZhaoxin ChenWanfang |
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| Abstract: | ThealterationsofNa -K -ATPase,Ca2 -ATPaseandMg2 -ATPaseactivitiesinerythrocytemembraneofgoatsandprotectionofanisodaminewerestudiedbyintravenousinjectionof E.Coli endotoxin(1800EU/kgbodyweight)andaloneaswellasincombination E.Coli endotoxintreatmentgroup(group)ledtoamarkedincreaseofthreeATPaseactivitiesoferythrocytemembraneat1hand3h,asignificantdecreaseat5h,7h,9h,12h invivo,ascomparedtothenormalcontrol(group).ThreeATPaseactivitiesin E.Coli endotoxinandanisodaminecoexposuregroup(group)werehigherthanthoseofgroupandgroup,exceptnosignificantdifferenceat9hand12hascomparedtogroupduringallexperiment.Theseresultsindicatedthat EColi endotoxincouldactivatethreeATPaseactivitiesonthemembraneintheprimarystageofadiministrationofendotoxin,soonafterwards,endotoxininhibitedthreeATPaseactivities,whereasanisodaminehadaprominenteffectofprotectiononthethreeATPaseoferythrocytemembraneofgoats invivo. |
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| Keywords: | Endotoxin Anisodamine Adenosinetriphosphatase(ATPase) Erythrocytemembrane Goat |
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