| 纳豆激酶研究进展 |
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| 引用本文： | 李淑英,赵仲麟,聂莹,马鑫,李燕,袁超,唐选明.纳豆激酶研究进展[J].中国农业科技导报,2013,15(4):139-143. |
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| 作者姓名： | 李淑英 赵仲麟 聂莹 马鑫 李燕 袁超 唐选明 |
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| 作者单位： | (1.中国农业科学院农产品加工研究所, 北京 100193,2.河南农业大学理学院, 郑州 450002,3.中国农业科学院农业信息研究所, 北京 100081,4.郑州轻工业学院食品与生物工程学院, 郑州 450002) |
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| 基金项目： | 中国农业科学院科技经费项目(2012 11)资助。 |
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| 摘 要： | 纳豆激酶是由枯草芽孢杆菌(Bacillus subtilis)分泌表达的碱性丝氨酸蛋白酶，具有极强的纤维蛋白溶解活性。研究表明，纳豆激酶纤溶活性强、副作用小，可用于开发溶栓药物。介绍了纳豆激酶的溶栓机理，就纳豆激酶的功效、生产菌种选育、发酵条件的优化、酶活性位点及定向进化等方面进行综述。
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| 关 键 词： | 纳豆激酶 纤维蛋白溶解活性 功效 抗血栓 |
Research Progress on Nattokinase |
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| LI Shu ying,ZHAO Zhong lin,NIE Ying,MA Xin,LI Yan,YUAN Chao,TANG Xua.Research Progress on Nattokinase[J].Journal of Agricultural Science and Technology,2013,15(4):139-143. |
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| Authors: | LI Shu ying ZHAO Zhong lin NIE Ying MA Xin LI Yan YUAN Chao TANG Xua |
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| Institution: | (1.Institute of Agro products Processing Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100081|2.College of Sciences, Henan Agricultural University, Zhengzhou 450002|3.Agricultural Information Institute, CAAS, Beijing 100081|4.School of Food and Biological Engineering, Zhengzhou College of Light Industry, Zhengzhou 450002, China) |
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| Abstract: | Nattokinase is a serine proteinase and fibrinolytic enzyme from Bacillus subtilis. Research indicated that nattokinase has strong fibrinolytic activity and few side effects, which could be developed as a promising agent for thrombosis therapy. This paper introduced nattokinase mechanism of action, its kinas efficacy, strain selection and breeding, optimisation of fermentation condition, enzyme activity sites and directed evolution, etc. |
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| Keywords: | nattokinase fibrinolytic activity efficacy anti thrombosis |
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