| 泰乐菌素的急性及蓄职毒性研究 |
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| 引用本文： | 史晓丽,沈丽琳,刘文兴.泰乐菌素的急性及蓄职毒性研究[J].畜牧与兽医,1996(1). |
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| 作者姓名： | 史晓丽 沈丽琳 刘文兴 |
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| 作者单位： | 南京农业大学动物医学院 |
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| 摘 要： | 对国产酒石酸泰乐菌素采用改进ｋａｒｂｅｒ法计算ＬＤ５０值，小白鼠和鸡分别为１２２２０ｍｇ／ｋｇ，２１９０ｍｇ／ｋｇ，与国外报道小鼠＞５０００～６２００ｍｇ／ｋｇ、鸡２１２２～５４００ｍｇ／ｋｇ基本一致；由此说明该药对小鼠基本无毒，对鸡为低毒。本试验还对小鼠经２０天递增给药，蓄积系数大于５．３。提示该药可作为饲料添加剂长期服用不致引起蓄积中毒。
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| 关 键 词： | 泰乐菌素，急性毒性试验，蓄积毒性试验 |
STUDY ON THE ACUTE AND ACCUMULATIVE TOXICITY OF TYLOSIN |
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| Shi Xiaoli, Shen Lilin and Liu Wcexin.STUDY ON THE ACUTE AND ACCUMULATIVE TOXICITY OF TYLOSIN[J].Animal Husbandry & Veterinary Medicine,1996(1). |
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| Authors: | Shi Xiaoli Shen Lilin and Liu Wcexin |
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| Abstract: | LD50 of Tylosin tartrate(made in China)is determined by improved Karber method in this paper.Thedata in mousc is 12220 mg/kg and 2190 mg/kg in chicken,The results are in general agrcement with the results insome literatures which are over 5000～6200 mg/kg in mousc and 2122～5400 mg/kg in chicken.Our results suggestthat Tylosin tartrate(made in China)approximately has no toxicity in mouse and low tokicity in chicken. Theaceumulation coefficient in mouse determined by dose progressive incrcasc method in twenty days is over 5.3.It can therefore be concluded that Tylosin lartrate can be used in a long period of time as a feed additive and doesn′t causeaccumulative poisoning. |
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| Keywords: | Tylosin Acute toxicity expriment Accumulative toxicity expriment |
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