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| 喹烯酮磺酸盐的制备及生物活性研究 | |
| 引用本文： | 张铎,尚若锋,王学红,廖健雄,李贵玉,刘宇,郝宝成,陶蕾,梁剑平.喹烯酮磺酸盐的制备及生物活性研究[J].中兽医医药杂志,2013,32(2):14-16. |
| 作者姓名： | 张铎 尚若锋 王学红 廖健雄 李贵玉 刘宇 郝宝成 陶蕾 梁剑平 |
| 作者单位： | 1. 兰州理工大学生命科学与工程学院,甘肃兰州,730050 2. 中国农业科学院兰州畜牧与兽药研究所,甘肃兰州,730050 3. 浙江海正药业股份有限公司,浙江台州,318000 |
| 摘 要： | 为进一步提高喹烯酮溶解度,以乙酰甲喹为原料,与带有助溶磺酸盐团的苯甲醛进行Claisen-Schumidt缩合反应。HPLC测定结果显示,其溶解度较喹烯酮提高约9 000倍;初步的抑菌活性测定结果表明,其抑菌活性与喹烯酮接近。 |
| 关 键 词： | 喹烯酮 溶解度 抑菌活性 |
Preparation of Quinocetone sulfonates and study on its antibacterial activities |
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| ZHANG Duo,SHANG Ruo-feng,WANG Xue-hong,LIAO Jian-xiong,LI Gui-yu,LIU Yu,HAO Bao-cheng,TAO Lei,LIANG Jian-ping.Preparation of Quinocetone sulfonates and study on its antibacterial activities[J].Journal of Traditional Chinese Veterinary Medicine,2013,32(2):14-16. | |
| Authors: | ZHANG Duo SHANG Ruo-feng WANG Xue-hong LIAO Jian-xiong LI Gui-yu LIU Yu HAO Bao-cheng TAO Lei LIANG Jian-ping |
| Institution: | 1.Lanzhou University of Technology,Lanzhou Gansu 730050;2.Lanzhou Institute of Husbandry and Pharmaceutical Sciences,Chinese Academy of Agricultural Sciences,Lanzhou Gansu 730050;3.Zhejiang Hisun Pharmaceutical Co.Ltd,Taizhou Zhejiang 318000,China) |
| Abstract: | Quinocetone derivatives a was designed and synthesized by Claisen-Schumidt condensation reaction between Mequindox and benzaldehyde.HPLC test showed that the solubility of the derivatives a was increased by about 9 000 times.Preliminary antibacterial test in vitro showed that its bacteriostatic activity was superior to Quinocetone. |
| Keywords: | Quinocetone solubility antibacterial activity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |