| 金樱子多糖对阿霉素的增效减毒作用 |
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| 引用本文： | 姚佳,彭梅,杨娟.金樱子多糖对阿霉素的增效减毒作用[J].贵州大学学报(农业与生物科学版),2012(4):338-340,362. |
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| 作者姓名： | 姚佳 彭梅 杨娟 |
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| 作者单位： | [1]贵州大学生命科学学院,贵州贵阳550025 [2]贵州省中国科学院天然产物化学重点实验室,贵州贵阳550002 |
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| 基金项目： | 贵州省社会发展科技攻关计划项目[（黔科合SY字（2011）3022号）] |
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| 摘 要： | 无菌抽取培养在小鼠腹腔内生长良好的S180腹水瘤制成匀浆,右腋接种,建立小鼠S180实体瘤模型。连续给药10 d,通过计算抑瘤率、q值、脾脏指数、胸腺指数,检测白细胞(WBC)、红细胞(RBC),Elisa法测定脾脏的超氧化物歧化酶(SOD)、丙二醛(MDA),判断金樱子多糖(RLP)对阿霉素(ADM)的增效减毒作用。结果表明:ADM单用抑瘤率为32.57%,与RLP合用后抑瘤率提高(q>1.15);RLP高剂量与ADM合用组与单用ADM组比较,外周血细胞(RBC、WBC)、脏器指数、SOD均明显增加(P<0.05),而MDA明显降低(P<0.05),说明金樱子多糖与化疗药物阿霉素合用后具有明显的增效减毒作用。
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| 关 键 词： | 金樱子多糖 S180 增效减毒 |
Synergistic and Attenuated Effects of Rosa Laevigata Michx Polysaccharides on Adriamycin |
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| YAO Jia,PENG Met,YANG Juan.Synergistic and Attenuated Effects of Rosa Laevigata Michx Polysaccharides on Adriamycin[J].Journal of Mountain Agriculture & Biology,2012(4):338-340,362. |
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| Authors: | YAO Jia PENG Met YANG Juan |
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| Institution: | 1. College of Life Sciences, Guizhou University, Guizhou Guiyang 550025, China ;2. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese A- cademy of Sciences, Guizhou Guiyang 550002, China) |
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| Abstract: | The S180 cavityascites tumor, cultured in the abdomen of mice was aseptically extracted and ho- mogenized, subsequently a tumor mouse model was established by right axillary vaccination 0.2 mL S180 in the present investigation. After 10 d consecutive administration, the inhibitory rate of tumor, q value, thymus in- dex and spleen index, white blood cells in serum, activity of spleen superoxide dismutase （SOD） , malondi- aldehyde （MDA） accumulation were quantified. The results showed the combined groups of RLP and ADM enhanced the anti-tumor effects （ q 〉 1.15 ） , and reduced the toxicity of adriamycin. The combined groups of high dose RLP and ADM increased peripheral blood cell, organ index and the activity of SOD （ P 〈 0.05 ） , while reduced the level of MDA（ P 〈 0.05 ）. RLP demonstrated significantly synergistic and attenuated effects on Adriamycin. |
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| Keywords: | Rosa Laevigata Michx Polysaccharides S180 synergistic and attenuated effects |
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