| 雏鸡感染网状内皮组织增殖病病毒后免疫病理的研究 |
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| 引用本文： | 刘忠贵,李广兴,阿合买提·买买提,郑世民,杨丽萍.雏鸡感染网状内皮组织增殖病病毒后免疫病理的研究[J].中国农业科学,2000,33(2):86-91. |
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| 作者姓名： | 刘忠贵 李广兴 阿合买提·买买提 郑世民 杨丽萍 |
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| 作者单位： | 东北农业大学动物医学院,哈尔滨,150030 |
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| 摘 要： | 研究了 1日龄 SPF雏鸡感染网状内皮组织增殖病病毒 ( REV)后 ,胸腺和脾脏 T细胞增殖反应及 T细胞数量、法氏囊和脾脏 B细胞增殖反应和抗体生成细胞数量、胸腺和脾脏 IL- 2及 IFN诱生活性的动态变化。结果发现 ,雏鸡感染 REV后 ,胸腺和脾脏 T细胞增殖反应及数量、法氏囊和脾脏 B细胞增殖反应和 Ig G+、Ig M+、Ig A+抗体生成细胞数量均明显低于未感染对照雏鸡 ;胸腺和脾脏 IL- 2及脾脏 IFN诱生活性显著下降 ,表明感染 REV后雏鸡中枢和外周免疫器官细胞免疫和体液免疫降低及细胞因子 IL- 2及 IFN免疫调节减弱。
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| 关 键 词： | SPF雏鸡 网状内皮组织增殖病病毒(REV) T、B细胞增殖反应 抗体生成细胞 IL-2 IFN |
| 修稿时间： | 1999-05-31 |
Study on the Immunopathological Changes of Chicken Infected with Reticuloendotheliosis Virus |
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| Liu Zhonggui,Li Guangxing,Ahmat·Mamat,Zheng Shimin,Yang Liping.Study on the Immunopathological Changes of Chicken Infected with Reticuloendotheliosis Virus[J].Scientia Agricultura Sinica,2000,33(2):86-91. |
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| Authors: | Liu Zhonggui Li Guangxing Ahmat·Mamat Zheng Shimin Yang Liping |
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| Abstract: | The experiment was conducted to study the T cell proliferative response and T cells number in thymus and spleen, the B cell proliferative response and antibody producing cells in Bursa of Fabricius and spleen and the inductive activity of interlukine 2 (IL 2)and interferon (IFN)in thymus and spleen of specific pathogen free(SPF) chickens infected with reticuloendotheliosis virus(REV). The results showed that the proliferative response and number of T cells in thymus and spleen, the proliferative response of B cells and number of IgG ,IgM ,IgA antibody producing cells in Bursa of Fabricicus and spleen and the inductive activity of IL 2 and IFN in thymus and spleen of chicken infected with REV were decreased.These indicated that REV infection in SPF chickens could produce dramatic decrease in cellular and humoral immunity and immunoregulation in the immune organs. |
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| Keywords: | SPF chickens Reticuloendotheliosis virus T B proloferative response Antibody producing cells IL 2 IFN |
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