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| 白花蛇舌草注射液对荷瘤小鼠免疫功能影响的研究 | |
| 引用本文： | 马天舒,葛迎春,任慧君,贾玉红,刘平,毋英杰,刘建旋.白花蛇舌草注射液对荷瘤小鼠免疫功能影响的研究[J].特产研究,2010,32(3):5-7,12. |
| 作者姓名： | 马天舒 葛迎春 任慧君 贾玉红 刘平 毋英杰 刘建旋 |
| 作者单位： | 1. 大连市中医研究所,辽宁大连,116013 2. 大连医科大学病生教研室,辽宁大连,116027 3. 吉林省中医药科学院,长春,130021 |
| 摘 要： | 研究白花蛇舌草注射液对荷瘤小鼠免疫功能的影响。应用比色法,分别测定白花蛇舌草注射液在高(15 mg生药/kg)、中(7.5 mg生药/kg)、低(3.75 mg生药/kg)3种剂量作用下,荷瘤小鼠脾脏NK细胞毒指数、脾细胞的增殖、腹腔巨噬细胞吞噬百分率及指数、血清凝集素活性和脾细胞IL-2活性的变化。与荷瘤对照组比较,白花蛇舌草注射液各剂量组可显著提高NK细胞活性(P0.01,P0.05);增强脾细胞增殖(P0.01,P0.05);显著提高腹腔巨噬细胞的吞噬功能(P0.001,P0.01,P0.05);显著增加血清中抗羊红细胞凝集素值(P0.001、P0.01);高、中剂量组可明显提高脾脏IL-2活性(P0.01,P0.05)。白花蛇舌草注射液具有显著提高荷瘤小鼠免疫功能的作用。 |
| 关 键 词： | 白花蛇舌草 注射液 荷瘤小鼠 NK细胞 |
Effects of Hedyotis diffusa Injection on Immune Function of Tumor-bearing Mice |
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| MA Tian-shu,GE Ying-chun,REN Hui-jun,JIA Yu-hong,LIU Ping,WU Ying-jie,LIU Jian-xuan.Effects of Hedyotis diffusa Injection on Immune Function of Tumor-bearing Mice[J].Special Wild Economic Animal and Plant Research,2010,32(3):5-7,12. | |
| Authors: | MA Tian-shu GE Ying-chun REN Hui-jun JIA Yu-hong LIU Ping WU Ying-jie LIU Jian-xuan |
| Institution: | 1.Department of Pharmacology, Institute of Traditional Chinese Medicine of Dalian, Dalian 116013, China; 2.Department of Pathophysiology, Dalian Medical University, Dalian 116027, China; 3.Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province, Changehun 130021, China) |
| Abstract: | To study the effects of Hedyotis diffusa injection on immune function of tumor-bearing mice. The following items were determined by using colorimetry： Cytotoxic index of the NK cells, proliferation of the spleen ceils, phagocytic percentage and the index of the abdomen macrophages, agglutinating activity from serum to the sheep erythrocytes and IL-2 activity of the spleen ceils in the tumor-bearing mice treated with high-,moderate- or low-dosage of Hedyotis diffusa injection （15,7.5,3.25 mg per kilogram ）. Compared to the tumor-bearing groups, the cytotoxic index of the NK cells, proliferation of the spleen cells, phagocytic percentage and the index of the abdomen macrophages, agglutinating activity increased significantly（ P 〈 0.001, P 〈 0.01, P 〈 0.05 ）. The IL-2 activity increased significantly at high and moderate-dosage （P 〈 0.01, P 〈 0.05 ）. The Hedyotis diffusa injection plays an important role in enhancing the immune function of tumor-bearing mice. |
| Keywords: | Hedyotis diffus a Injection Tumor-bearing mice NK cell |
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