| 细胞周期蛋白D1在梅花鹿茸角中的表达 |
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| 引用本文： | 张晨,;曹航,;李当当,;杨占清,;方青,;郭斌,;岳占碰.细胞周期蛋白D1在梅花鹿茸角中的表达[J].兽医大学学报,2014(7):1153-1156. |
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| 作者姓名： | 张晨 ;曹航 ;李当当 ;杨占清 ;方青 ;郭斌 ;岳占碰 |
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| 作者单位： | [1]吉林大学动物医学学院,吉林长春130062; [2]吉林医药学院,吉林吉林132013 |
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| 基金项目： | 吉林大学大学生创新计划资助项目（2012A81216）; 国家自然科学基金资助项目（31372390） |
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| 摘 要： | 以梅花鹿为研究对象,通过原位杂交方法对细胞周期蛋白D1（cyclin D1）在梅花鹿茸角中的表达进行了研究。结果显示,cyclin D1在梅花鹿茸角表皮层内表达极少,在茸角真皮层、间充质层及软骨层等处均有表达,但在表达强度上存在差异。在真皮层中,cyclin D1在真皮成纤维细胞中有较强的表达,在鹿茸间充质细胞中也有少量cyclin D1的表达,在鹿茸软骨层中,cyclin D1在软骨细胞中的表达量非常高,主要表达在增殖区的软骨细胞中。结果表明,cyclin D1可能在梅花鹿茸角再生过程中起重要的调控作用。
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| 关 键 词： | 细胞周期蛋白D1 梅花鹿 鹿茸 再生 |
Expression of cyclin D1 in sika deer antlers |
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| Institution: | ZHANG Chen , CAO Hang, LI Dang-dang , YANG Zhan-qing , FANG Qing, GUO Bin , YUE Zhan-peng(1. College of Veterinary Medicine,Jilin Uniwersity,Changchun 130062,China; 2. Jilin Medical College ,Jilin City ,J ilin 132013 ,China) |
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| Abstract: | This investigation aimed to use the sika deer as a model to study the expression of cyclin D1 in deer antlers using in situ hybridization.The results showed that the little expression of cyclin D1 mRNA signal was detected in epidermis of sika deer antlers.The expression signal of cyclin D1mRNA was also observed in the dermis,mesenchyme and cartilage,but there was a difference in the expression level.In the dermis,a high level of cyclin D1mRNA signal was found in the dermal fibroblasts.However,only a low level of cyclin D1 mRNA signal was detected in the mesenchymal cell.Cyclin D1mRNA was strongly expressed in the antler chondrocytes,and mainly expressed in the growth plate cartilage of deer antler.These results suggest that cyclin D1may play an important role in the process of sika deer antler regeneration. |
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| Keywords: | cyclin D1 sika deer antlers regeneration |
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