Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae) |
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| Authors: | Khalijah Awang Xe-Min Loong Kok Hoong Leong Unang Supratman Marc Litaudon Mat Ropi Mukhtar Khalit Mohamad |
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| Institution: | 1. Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia;2. Department of Pharmacy, University of Malaya, 50603 Kuala Lumpur, Malaysia;3. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, 45363 Jatinangor, Indonesia;4. Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France |
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| Abstract: | A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids and steroids were measured in vitro for their cytotoxic activities against eight cancer cell lines; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, 24(E)-cycloart-24-ene-26-ol-3-one 1, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC50 11.5 μM). |
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| Keywords: | Aglaia exima Meliaceae Cycloartane Cytotoxicity Steroids 24(E)-cycloart-24-ene-26-ol-3-one |
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