New flavane gallates isolated from the leaves of Plicosepalus curviflorus and their hypoglycemic activity |
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Authors: | Areej Mohammad Al-Taweel Shagufta Perveen Ghada Ahmed Fawzy Saleh Ibrahim Alqasoumi Kamal EH El Tahir |
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Institution: | 1. Department of Pharmacogonosy, College of Pharmacy, King Saud University, Riyadh, P.O. Box 2457, Riyadh 11451, Saudi Arabia;2. Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt;3. Department of Pharmacology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia |
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Abstract: | Two new flavane gallates were isolated from the leaves of Plicosepalus curviflorus. The structure of the new compounds was established as 2S,3R-3,3′,4′,5,7-pentahydroxyflavane-5-O-gallate (1) and 2S,3R-3,3′,4′,5,5′,7-hexahydroxyflavane-4′,5-di-O-gallate (2), respectively. In addition, seven known compounds (−)-catechin (3), quercetin (4), lupeol (5), β-sitosterol (6), pomolic acid (7), β-sitosterol 3-O-β-d-glucopyranoside (8) and 4-methoxycinnamic acid (9) were reported for the first time from the genus Plicosepalus. Compounds 1, 2 and 3 were investigated for their hypoglycemic activity and showed significant hypoglycemic activity in Swiss Albino mice. |
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Keywords: | Plicosepalus curviflorus Flavane gallates Hypoglycemic activity |
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