A cytotoxic cardenolide and a saponin from the rhizomes of Tupistra chinensis |
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| Authors: | Zheng-Hong Pan Yan Li Jin-Lei Liu De-Sheng Ning Dian-Peng Li Xing-De Wu Yong-Xin Wen |
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| Institution: | 1. Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, China;2. Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China |
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| Abstract: | A new cardenolide tupichinolide (1) and a new steroidal saponin tupichinin A (2), together with seven known compounds, were isolated from the rhizomes of Tupistra chinensis. Their structures were established using spectroscopic analysis and chemical methods. Compound 1 was the first cardenolide isolated from Tupistra chinensis and exhibited potent cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480. |
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| Keywords: | Tupistra chinensis Cardenolide Steroidal saponin Tupichinolide Tupichinin A Cytotoxicity |
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