Contribution of methylated exudate flavonoids to the anti-inflammatory activity of Grindelia robusta |
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| Authors: | Liselotte Krenn Eckhard Wollenweber Katja Steyrleuthner Cornelia Görick Matthias F Melzig |
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| Institution: | 1. Department of Pharmacognosy, University of Vienna, PharmaCenter Vienna, Althanstr. 14, A-1090 Vienna, Austria;2. Institut für Botanik der TU Darmstadt, Schnittspahnstrasse 3, D-64287 Darmstadt, Germany;3. Department of Pharmacy, Freie Universität Berlin, Königin-Luise-Str., 2 U. 4, D-14195 Berlin, Germany |
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| Abstract: | The flavonoid pattern of an acetonic extract of Grindelia robusta Nutt. was investigated in detail. The flavonoids were enriched by CC. In addition to twelve known methylated exudate flavonols four compounds were identified for the first time in G. robusta. Several substances of the flavonoid complex, among them the main compounds quercetin-3-methylether and 6-OH-kaempferol-3,6-dimethylether, were tested for their activity to inhibit neutrophil elastase. Quercetin-3-methylether was shown to be most active with an IC50 of 19 µM, thus obviously contributing to the anti-inflammatory activity of the drug. |
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| Keywords: | Grindelia robusta Methylated flavonoids Inhibition of neutrophil elastase |
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