Gastroprotective mechanism of Vanillosmopsis arborea bark essential oil |
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| Authors: | Gerlânia de O Leite Antonia Rosângela da Penha Cícera N Fernandes Heloísa Helena F Souza José Galberto M da Costa Adriana R Campos |
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| Institution: | 1. Laboratório de Pesquisas em Produtos Naturais, Universidade Regional do Cariri, Crato, Brazil;2. Vice-Reitoria de Pesquisa e Pós-Graduação, Universidade de Fortaleza, Fortaleza, Brazil |
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| Abstract: | This study was aimed to clarify the mechanism of gastroprotection by Vanillosmopsis arborea Baker essential oil (EOVA) using ethanol-induced gastric mucosal damage in mice. Gastric lesions were significantly reduced by EOVA (200 and 400 mg/kg). Chemical analysis showed that the major compound of EOVA was α-bisabolol. Pretreatment of mice with yohimbine, the α2-antagonist, greatly suppressed the gastroprotective effect of OEVA. Furthermore, OEVA gastroprotection was not attenuated in mice pretreated with indomethacin, L-NAME or glibenclamide, the respective inhibitors of cyclooxygenase, nitric oxide synthase and K+ATP channel activation. These data suggest that OEVA affords gastroprotection most possibly by α2-receptor activation. |
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| Keywords: | Vanillosmopsis arborea Baker Asteraceae Gastroprotection Mechanism α-bisabolol α2-receptor |
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