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Swietenine: A potential oral hypoglycemic from Swietenia macrophylla seed |
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| Authors: | Saikat Dewanjee Anup Maiti Anup K Das Subhash C Mandal Sankar P Dey |
| Institution: | 1. Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, India;2. Pharmacy College, Azamgarh, Uttar Pradesh, India;3. Department of Pharmaceutical Sciences, Dibrugarh University, Assam, India;4. Shrikrisna College, Bagula, Nadia, India |
| Abstract: | Swietenine, a tetranortriterpenoid, was isolated from the Swietenia macrophylla seeds. The in vivo hypoglycemic activity was evaluated against neonatal-streptozotocin induced type 2 diabetic rats. Oral administration of swietenine at 25 and 50 mg/kg body weight per day to diabetic rats was found to possess significant dose dependant hypoglycemic and hypolipidemic activity in type 2 diabetic rats. |
| Keywords: | Hypoglycemic Type 2 diabetes Swietenia macrophylla Swietenine |
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