| 体外药动模型中诺氟沙星对嗜水气单胞菌的药动及药效研究 |
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| 引用本文： | 陈俭清,卢彤岩.体外药动模型中诺氟沙星对嗜水气单胞菌的药动及药效研究[J].大连水产学院学报,2010,25(3):219-223. |
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| 作者姓名： | 陈俭清 卢彤岩 |
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| 作者单位： | 1. 中国水产科学研究院,淡水渔业研究中心,农业部水生动物遗传育种和养殖生物学重点开放实验室,江苏,无锡,214081;东北农业大学,动物医学学院,黑龙江,哈尔滨,150030
2. 中国水产科学研究院,淡水渔业研究中心,农业部水生动物遗传育种和养殖生物学重点开放实验室,江苏,无锡,214081;中国水产科学研究院,黑龙江水产研究所,黑龙江,哈尔滨,150070 |
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| 基金项目： | 农业部水生动物遗传育种和养殖生物学重点开放实验室基金资助项目，"十一五"国家科技支撑计划项目，农业公益性行业专项 |
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| 摘 要： | 通过建立体外药动模型的方法,研究诺氟沙星对嗜水气单胞菌Aerom onas hydrophila的药动-药效（简称PK-PD）参数。结果表明：在消除半衰期为3.4 h的模型内,2M IC（最小抑菌浓度）、4M IC和8M IC的诺氟沙星对嗜水气单胞菌能够抑制4 h,4 h后细菌出现再生长,而16M IC的诺氟沙星对嗜水气单胞菌能够起到持续的抑制作用;在消除半衰期为77 h的模型内,2M IC的诺氟沙星对嗜水气单胞菌能够抑制4 h,4 h后细菌出现再生长,而4M IC、8M IC和16M IC对嗜水气单胞菌能够起到持续的抑制作用。消除半衰期为3.4 h的模型内,当AUC0→24 h/M IC（药时曲线下面积与最小抑菌浓度的比值）〉42.43±9.21,Cm ax/M IC（峰浓度与最小抑菌浓度的比值）〉15.78±0.22时,诺氟沙星对嗜水气单胞菌能够起到持续的抑制作用;消除半衰期为77 h的模型内,当AUC0→24 h/M IC〉41.87±10.16,Cm ax/M IC〉4.79±0.11时,诺氟沙星对嗜水气单胞菌能够起到持续的抑制作用。
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| 关 键 词： | 体外药动模型 诺氟沙星 嗜水气单胞菌 |
Pharmacodynamic effect of norfloxacin against Aeromonas hydrophila in vitro pharmacokinetic model |
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| CHEN Jian-qing,LU Tong-yan.Pharmacodynamic effect of norfloxacin against Aeromonas hydrophila in vitro pharmacokinetic model[J].Journal of Dalian Fisheries University,2010,25(3):219-223. |
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| Authors: | CHEN Jian-qing LU Tong-yan |
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| Institution: | CHEN Jian-qing1,2,LU Tong-yan1,3(1.Key Laboratory of Genetic Breeding , Aquaculture Biology of Freshwater Fishes,Agriculture Ministry,PRC,Wuxi 214081,China,2.College of Veterinary Sciences,Northeast Agricultural University,Harbin 150030,3.Pearl River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Guangzhou 510380,China) |
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| Abstract: | The pharmacokinetic parameters(PK-PD parameter) of norfloxacin against bacterium Aeromonas hydrophila was studied by vitro pharmacokinetic models.In vitro model with elimination half-life of 3.4 h,the bacterium was inhibited for 4 h by 2MIC,4MIC and 8 MIC norfloxacin and continuously inhibited in the 24 h entire experiment by 16 MIC norfloxacin.In the vitro model with elimination half-life of 77 h,the inhibitory effect of 2MIC norfloxacin against the bacterium was continued for 4h and then the bacterium reg... |
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| Keywords: | in vitro pharmacokinetic model norfloxacin Aeromonas hydrophila |
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