| 蕨麻多糖对小鼠免疫功能的影响 |
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| 引用本文： | 陈炅然,胡庭俊,张瑞孝,程富胜,孟聚诚,高芳.蕨麻多糖对小鼠免疫功能的影响[J].中兽医医药杂志,2005,24(2):14-16. |
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| 作者姓名： | 陈炅然 胡庭俊 张瑞孝 程富胜 孟聚诚 高芳 |
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| 作者单位： | 1. 中国农业科学院兰州畜牧与兽药研究所,甘肃,兰州,730050
2. 皋兰县畜牧站 |
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| 摘 要： | 用环磷酰胺作为免疫抑制剂小鼠腹腔注射(100mg/kg)建立免疫抑制模型,观察不同剂量蕨麻多糖(50、100、200、400mg/kg)对小鼠脾脏指数、胸腺指数及血清溶菌酶活力的影响.结果显示,蕨麻多糖能明显提高正常小鼠脾脏指数、胸腺指数及免疫抑制小鼠脾脏指数;增强正常小鼠和免疫抑制小鼠血清溶菌酶活力,尤其在免疫抑制状态下,增强作用更明显.表明该多糖可对抗Cy所致的免疫抑制,明显地增强小鼠免疫功能.
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| 关 键 词： | 蕨麻多糖 环磷酰胺 脾脏指数 胸腺指数 血清溶菌酶 |
| 文章编号： | 1000-6354(2005)02-0014-03 |
| 修稿时间： | 2004年12月18 |
Effects of Potentilla anserine polysaccharide on immune functions in mice |
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| CHEN Jiong-ran,HU Ting-jun,CHENG Fu-sheng,ZHANG Rui-xiao,MENG Ju-cheng,GAO Fang.Effects of Potentilla anserine polysaccharide on immune functions in mice[J].Journal of Traditional Chinese Veterinary Medicine,2005,24(2):14-16. |
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| Authors: | CHEN Jiong-ran HU Ting-jun CHENG Fu-sheng ZHANG Rui-xiao MENG Ju-cheng GAO Fang |
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| Abstract: | The study was carried out to investigate thymus index, splenic index and the level of serum activity of lysozyme in mice treated with cyclophosphamide (Cy)(100mg/kg) in vivo by intraperitoneal injection at different Potentilla anserine polysaccharide (PAP) doses of 50 mg/kg,100 mg/kg ,200 mg/kg or 400 mg/kg. The result showed that intraperitoneal administration of the polysaccharide could siginificantly raise the thymus and spleen indices and increase the serum activity of lysozyme in a dose-dependent manner. In conclusion, Potentilla anserine polysaccharide was able to overcome cyclophosphamide-induced immunosuppression, and had markedly immunomodulation functions. |
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| Keywords: | Potentilla anserine polysaccharide (PAP) cyclophosphamide (Cy) thymus index splenic index serum activity of lysozyme |
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