Germinated brown rice relieves hyperlipidemia by alleviating gut microbiota dysbiosis |
| |
| Authors: | REN Chuan-ying ZHANG Shan HONG Bin GUAN Li-jun HUANG Wen-gong FENG Jun-ran SHA Di-xin YUAN Di LI Bo JI Ni-na LIU Wei LU Shu-wen |
| |
| Institution: | 1. Food Processing Research Institute, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, P.R.China;2. Heilongjiang Province Key Laboratory of Food Processing, Harbin 150086, P.R.China;3. Safety and Quality Institute of Agricultural Products, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, P.R.China;4. Soybean Research Institute, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, P.R.China;5. The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, P.R.China |
| |
| Abstract: | Hyperlipidemia is a frequent metabolic disorder that is closely associated with diet. It is believed that brown rice, containing the outer bran layer and germ, is beneficial for the remission of hyperlipidemia. This study established a rat model of hyperlipidemia by feeding a high-fat diet. The hypolipidemic potential of germinated brown rice (Gbrown) and germinated black rice (a germinated black-pigmented brown rice, Gblack) were explored in the model rats, mainly in the aspects of blood lipids, lipases, apolipoproteins, and inflammation. The gut microbiota in hyperlipidemic rats receiving diverse dietary interventions was determined by 16S rDNA sequencing. The results showed that the intervention of Gbrown/Gblack alleviated the hyperlipidemia in rats, evidenced by decreased TC, TG, LDL-C, and apolipoprotein B, and increased HDL-C, HL, LPL, LCAT, and apolipoprotein A1. Gbrown/Gblack also weakened the inflammation in hyperlipidemia rats, evidenced by decreased TNF-α, IL-6, and ET-1. In addition, 16S rDNA sequencing revealed that the diet of Gbrown/Gblack elevated the abundance and diversity of gut microbiota in hyperlipidemia rats. At the phylum level, Gbrown/Gblack decreased Firmicutes, increased Bacteroidetes, and decreased the F/B ratio in hyperlipidemia rats. At the genus level, Gbrown/Gblack decreased Streptococcus and increased Ruminococcus and Allobaculum in hyperlipidemia rats. Some differential microbial genera relating to lipid metabolism were also determined, such as the Lachnospira and Ruminococcus in the Gblack group, and the Phascolarctobacterium, Dorea, Turicibacter, and Escherichia-Shigella in the Gbrown group. Notably, the beneficial effect of Gblack was stronger than Gbrown. To sum up, the dietary interventions of Gbrown/Gblack contributed to the remission of hyperlipidemia by alleviating the dysbiosis of gut microbiota. |
| |
| Keywords: | hyperlipidemia germination brown rice black rice gut microbiota |
| 本文献已被 ScienceDirect 等数据库收录！ |
| 点击此处可从《农业科学学报(英文版)》浏览原始摘要信息 |
| 点击此处可从《农业科学学报(英文版)》下载免费的PDF全文 |
|
