| 法氏囊在鸡淋巴细胞性白血病发生发展中的作用 |
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| 引用本文： | 罗国玲,甘永华,李学斌.法氏囊在鸡淋巴细胞性白血病发生发展中的作用[J].畜牧与兽医,1999,31(1):5-7. |
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| 作者姓名： | 罗国玲 甘永华 李学斌 |
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| 作者单位： | 1. 河南职业技术师范学院牧医系,新乡,453003
2. 中国人民解放军农牧大学军事兽医研究所 |
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| 摘 要： | 用鸡淋巴细胞性白血病病毒ＲＡＶ－１株接种３５只１日龄伊莎鸡雏，于接毒后不同批次扑杀，采取法氏囊做组织学、免疫细胞化学、透射电镜观察。结果：接毒后１个月，法氏囊滤泡髓质淋巴细胞开始转化，接毒后２～５个月更明显，在法氏囊滤泡髓质区形成成淋巴细胞克隆增殖灶。接毒后６个月，法氏囊萎缩。生物素－亲和素（ＢＡ）法染色表明法氏囊一直存有病毒和群特异性抗原，以接毒后３～４个月含量最高。电镜观察，在接毒后１～４个月的实验鸡法氏囊滤泡髓质淋巴细胞、巨噬细胞和网状细胞中观察到淋巴细胞性白血病（ＬＬ）病毒粒子。组织学、免疫细胞化学和电镜观察都表明法氏囊是该病的主要靶器官之一，法氏囊在鸡淋巴细胞性白血病的发生发展中起一定的作用
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| 关 键 词： | 鸡 淋巴细胞性白血病 法氏囊 疾病发生发展 |
| 修稿时间： | 1998-04-20 |
The Function of the Bursa of Fabricius in the Development of Avian Lymphoid Leukosis |
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| Luo Guoling,Gan Yonghua,Li Xuebin.The Function of the Bursa of Fabricius in the Development of Avian Lymphoid Leukosis[J].Animal Husbandry & Veterinary Medicine,1999,31(1):5-7. |
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| Authors: | Luo Guoling Gan Yonghua Li Xuebin |
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| Abstract: | female Isa hens were inoculated with RAV 1 strain of lymphoid leukosis virus at 1 day of age.The birds were killed at different time of postinoculation(PI).The bursa samples were collected and observed with histological,immunocytochemistrical and transmitted electronic microscopical(TEM)techniques.The results showed that the lymphocytes in the medulla of the follicles in bursa were transformed and clonal proliferated lymphoblastic foci were formed in the medulla at the 1st to 5th month of PI.The bursa became atrophy at the 6th month of PI.Lymphoid leukosis virus (LLV)and group specific antigen in the follicles were observed with BA dying methold,especially high in concentration at the 3rd to 4th month of PI.With TEM observation,LLV particls were seen in the cytoplasm and on the membrane of the macrophages,in the cytoplasm of the reticular cells and between the lymphocytes in the bursa at the 1st to 4th month of PI.All of the results suggested that the bursa was one of main target organs of LLV and it played a certain role in the development of LL. |
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| Keywords: | chick lymphoid leukosis bursa of Fabricius disease development |
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