Effects of three infusion fluids with different sodium chloride contents on steady‐state serum concentrations of bromide in dogs |
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| Authors: | Koya Fukunaga Hikaru Matsumoto Michiko Wate Karin Misawa Miyoko Saito Hiroshi Matsuda Kensuke Orito |
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| Institution: | 1. Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan;2. Department of Physiology II, School of Veterinary Medicine, Azabu University, Sagamihara, Japan;3. Laboratory of Veterinary Surgery II, School of Veterinary Medicine, Azabu University, Sagamihara, Japan;4. Laboratory of Veterinary Molecular Pathology and Therapeutics, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan |
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| Abstract: | Potassium bromide overdose (bromism) in the management of canine epilepsy has been known. However, a protocol to reduce bromide concentrations rapidly has not been previously established. The effects of three infusion fluids with different chloride contents on the steady‐state serum concentrations of bromide in beagles were determined. After stabilization of the serum bromide concentrations, seven dogs were infused with saline (Na+ 154 mmol/L; Cl? 154 mmol/L), lactated Ringer's (Na+ 131 mmol/L; Cl? 110 mmol/L), or maintenance solutions (Na+ 35 mmol/L; Cl? 35 mmol/L) at a rate of 2 or 10 ml kg?1 hr?1 for 5 hr. Serum and urine were collected hourly, and the bromide concentrations were measured. When saline and lactated Ringer's solutions were infused at a rate of 10 ml kg?1 hr?1 for 5 hr, serum bromide concentrations were decreased by 14.24% and urine bromide concentrations by 17.63%, respectively. Of all compositions of infusion fluids, only sodium and chloride contents were associated with the decreased serum concentrations and the increased renal clearance of bromide. In summary, saline and lactated Ringer's solutions reduced serum bromide concentrations in a sodium chloride‐dependent manner in dogs were found when infused at 10 ml kg?1 hr?1 for 5 hr. |
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| Keywords: | beagle infusion fluid potassium bromide Ringer's lactate saline |
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