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5α-Reductase inhibitory component from leaves ofArtocarpus altilis |
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| Authors: | Kuniyoshi Shimizu Ryuichiro Kondo Kokki Sakai Supanida Buabarn Uraiwan Dilokkunanant |
| Institution: | (1) Department of Forest Products, Faculty of Agriculture, Kyushu University, 812-8581 Fukuoka, Japan;(2) Kasetsart Agriculture and Agro-Industrial Product Improvement Institute, Kasetsart University, Bangkok, Thailand |
| Abstract: | The inhibitory effects of 17 samples prepared from Thailand plants on 5 -reductase activity were examined. The acetone extract of leaves ofArtocarpus altilis showed potent 5-reductase inhibitory activity. Fractionation guided by 5-reductase inhibition led to the isolation of 2-geranyl-2 ,3,4,4-tetrahydroxydihydrochalcone from the acetone extract of leaves ofA. altilis. This compound showed more potent inhibitory effect (IC50=38 M) than-linolenic acid known as a naturally occurring potent inhibitor. |
| Keywords: | Artocarpus altilis (Parkins) Fosberg Moraceae Leaves 5 |
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