| TCDCA对IL-1β刺激下AA大鼠成纤维样滑膜细胞中PGE2分泌的影响 |
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| 引用本文： | TCDCA对IL ,刺激下AA大鼠成纤维样滑膜细胞中PGE分泌的影响.TCDCA对IL-1β刺激下AA大鼠成纤维样滑膜细胞中PGE2分泌的影响[J].畜牧与饲料科学,2021,42(5):1-5. |
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| 作者姓名： | TCDCA对IL 刺激下AA大鼠成纤维样滑膜细胞中PGE分泌的影响 |
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| 作者单位： | 1.内蒙古农业大学,内蒙古 呼和浩特 010018; 2.农业农村部动物疾病诊疗技术重点实验室,内蒙古 呼和浩特 010018; 3.内蒙古自治区农牧业科学院,内蒙古 呼和浩特 010031 |
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| 基金项目： | 内蒙古自治区自然科学基金项目（2016MS0348） |
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| 摘 要： | 目的] 进一步探讨牛磺鹅去氧胆酸（taurochenodeoxycholic acid,TCDCA）在抗炎免疫方面的潜在调节作用。方法] 以AA大鼠成纤维样滑膜细胞作为研究对象,采用ELISA方法检测TCDCA和IL-1β作用下AA大鼠成纤维样滑膜细胞上清液中PGE2的含量,分析TCDCA对IL-1β刺激下AA大鼠成纤维样滑膜细胞中PGE2分泌情况的影响。结果] TCDCA能够对IL-1β刺激下AA大鼠纤维样滑膜细胞PGE2的分泌产生下调作用（P<0.05）。结论] TCDCA对IL-1β刺激下AA大鼠成纤维样滑膜细胞中PGE2的分泌具有抑制作用,为TCDCA在兽医临床应用提供依据。
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| 关 键 词： | 牛磺鹅去氧胆酸 成纤维样滑膜细胞 前列腺素E2 |
| 收稿时间： | 2021-07-18 |
Effect of Taurochenodeoxycholic Acid on PGE2 Excretion of Fibroblast-like Synoviocytes in Adjuvant Arthritis Rats with Stimulation of IL-1β |
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| JIANG Xue-ying,QIAN Ying-hong,ZHAO Jun-li,ZHANG Kai,DUAN Yan,LI Pei-feng,HE Xiu-ling,MAO Wei,CAO Jin-shan,GUO Wen-rui.Effect of Taurochenodeoxycholic Acid on PGE2 Excretion of Fibroblast-like Synoviocytes in Adjuvant Arthritis Rats with Stimulation of IL-1β[J].Animal Husbandry and Feed Science,2021,42(5):1-5. |
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| Authors: | JIANG Xue-ying QIAN Ying-hong ZHAO Jun-li ZHANG Kai DUAN Yan LI Pei-feng HE Xiu-ling MAO Wei CAO Jin-shan GUO Wen-rui |
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| Institution: | 1. Inner Mongolia Agricultural University,Hohhot 010018,China; 2. Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease,Ministry of Agriculture and Rural Affairs,Hohhot 010018,China; 3. Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences,Hohhot 010031,China |
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| Abstract: | Objective] To further assess the potential anti-inflammatory and immunomodulatory roles of taurochenodeoxycholic acid （TCDCA）. Method] The fibroblast-like synoviocytes （FLS） of adjuvant arthritis （AA） rats were used as experimental research objects. The contents of prostaglandin E2（PGE2） in supernatant of FLS co-incubated with TCDCA and IL-1β were determined by ELISA to evaluate the effect of TCDCA on PGE2 excretion with stimulation of IL-1β. Result] TCDCA significantly （P<0.05） reduced the PGE2 excretion level with stimulation of IL-1β in FLS of AA rats. Conclusion] TCDCA has inhibitory effect on PGE2 excretion with stimulation of IL-1β in FLS of AA rats, which provides reference for application of TCDCA in veterinary clinic practice. |
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| Keywords: | taurochenodeoxycholic acid fibroblast-like synoviocytes prostaglandin E2 |
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