| 猪链球菌2型毒力因子及疫苗候选蛋白研究进展 |
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| 引用本文： | 吴萍萍.猪链球菌2型毒力因子及疫苗候选蛋白研究进展[J].畜牧与饲料科学,2013(11):123-127. |
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| 作者姓名： | 吴萍萍 |
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| 作者单位： | 池州职业技术学院,安徽池州247000 |
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| 摘 要： | 猪链球菌2型（ss2）是一种重要的人兽共患病病原菌，可引起人和猪发生严重疾病。SS2的经典毒力因子有荚膜抗原、溶菌酶释放蛋白、溶血素等。随着研究的深入．又发现了一些与SS2致病性相关的基因和毒力相关元件，以及一些蛋白酶类，这些毒力因子多数具有较好的免疫原性，并在链球菌致病和生长过程中发挥十分重要的作用。通过对一些具有免疫原性的SS2毒力因子蛋白片段进行体外重组表达，有望研制出有效预防SS2感染的基因工程疫苗。
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| 关 键 词： | 猪链球菌2型 毒力因子 疫苗候选蛋白 |
Research Advance in Streptococcus suis Type 2 Virulence Factors and Vaccine Candidate Proteins |
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| WU Ping-ping.Research Advance in Streptococcus suis Type 2 Virulence Factors and Vaccine Candidate Proteins[J].Animal Husbandry and Feed Science,2013(11):123-127. |
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| Authors: | WU Ping-ping |
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| Institution: | WU Ping-ping (Chizhou Vocational Technology College, Chizhou 247000, China) |
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| Abstract: | Streptococcus suis type 2 （SS2） is an important zoonosis pathogen, which can cause a variety of serious diseases in swine and human. The classic virulence factors of SS2 include capsular antigen, lysozyme released protein, hemolysin etc. In recent years, some new genes or components related to pathogenicity and virulence, and some proteases were found in SS2. The virulence factors mostly have good immunogenicity and play important role in pathogenicity and growth progress of Streptococcs sp.. Some immunogenic virulence factors by SS2 can be generated as recombinant proteins in vitro. These recombinant proteins are expected to produce gene engineering vaccines for effective preventing SS2 infection. |
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| Keywords: | Streptococcus suis type 2 virulence factors vaccine candidate proteins |
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