Coccidiosis: T-lymphocyte-dependent effects of infection with <span class="math"><math><mtext>Eimeria nieschulzi</mtext></math></span> in rats期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Coccidiosis: T-lymphocyte-dependent effects of infection with $Eimeria nieschulzi$ in rats

Authors:	MElaine Rose Patricia Hesketh

Institution:	Houghton Poultry Research Station, Houghton, Huntingdon, Cambridgeshire PE17 2DA Great Britain

Abstract:	The intestinal pathology caused by infection with $Eimeria nieschulzi$ was investigated and comparisons were made between the effects in athymic nude (rnu/rnu) rats and their heterozygous (rnu/+) litter-mates. Most of the changes noted, i.e. increase in gut weight, partial villous atrophy and increased numbers of mast, goblet and pyroninophilic cells were shown to be largely or wholely thymus dependent. The numbers of intraepithelial lymphocytes were decreased in both groups during the period of study. The peripheral blood leucocyte response was similar in both groups of rats during a primary infection but differed after a challenge inoculum, indicating that the secondary type of response which occurred in the rnu/+ rats was thymus dependent, as is resistance to reinfection.

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