Complete genome sequence of the apicomplexan, Cryptosporidium parvum |
| |
| Authors: | Abrahamsen Mitchell S Templeton Thomas J Enomoto Shinichiro Abrahante Juan E Zhu Guan Lancto Cheryl A Deng Mingqi Liu Chang Widmer Giovanni Tzipori Saul Buck Gregory A Xu Ping Bankier Alan T Dear Paul H Konfortov Bernard A Spriggs Helen F Iyer Lakshminarayan Anantharaman Vivek Aravind L Kapur Vivek |
| |
| Institution: | Department of Veterinary and Biomedical Science, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA. abe@umn.edu |
| |
| Abstract: | The apicomplexan Cryptosporidium parvum is an intestinal parasite that affects healthy humans and animals, and causes an unrelenting infection in immunocompromised individuals such as AIDS patients. We report the complete genome sequence of C. parvum, type II isolate. Genome analysis identifies extremely streamlined metabolic pathways and a reliance on the host for nutrients. In contrast to Plasmodium and Toxoplasma, the parasite lacks an apicoplast and its genome, and possesses a degenerate mitochondrion that has lost its genome. Several novel classes of cell-surface and secreted proteins with a potential role in host interactions and pathogenesis were also detected. Elucidation of the core metabolism, including enzymes with high similarities to bacterial and plant counterparts, opens new avenues for drug development. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
