| 口蹄疫灭活疫苗研究进展 |
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| 引用本文： | 张淑刚,张永光.口蹄疫灭活疫苗研究进展[J].动物医学进展,2008,29(12). |
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| 作者姓名： | 张淑刚 张永光 |
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| 作者单位： | 中国农业科学院兰州兽医研究所,家畜疫病病原生物学国家重点实验室,农业部畜禽病毒学重点开放实验室,农业部草食动物疫病重点开放实验室,甘肃,兰州,730046 |
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| 基金项目： | 国家支撑计划项目(2006BAD06A06) |
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| 摘 要： | 灭活疫苗仍然是当前口蹄疫免疫控制的主要疫苗，研制口蹄疫灭活疫苗具有重要的现实意义，其研制方法在不断丰富和完善。文章详细描述了口蹄疫灭活疫苗研制的重要步骤及其进展，包括毒株筛选，病毒生产、灭活、抗原浓缩、纯化和配苗及疫苗的质量控制。制苗毒株的选择是研制疫苗的首要问题，直接关系到疫苗的免疫效果；病毒灭活和随后的安全试验是在制备灭活FMD疫苗中最关键的步骤；抗原浓缩纯化和配苗是保证疫苗良好免疫效果的必需。最后阐述了口蹄疫灭活疫苗在口蹄疫防控中的作用。
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| 关 键 词： | 口蹄疫 灭活疫苗 研制 质量控制 作用 |
Progress on Inactivated Foot-and-mouth Disease Vaccines |
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| ZHANG Shu-gang,ZHANG Yong-guang.Progress on Inactivated Foot-and-mouth Disease Vaccines[J].Progress In Veterinary Medicine,2008,29(12). |
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| Authors: | ZHANG Shu-gang ZHANG Yong-guang |
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| Institution: | Key Laboratory of Grazing Animal Diseases of Ministry of Agriculture;Key Laboratory of Animal Virology of Ministry of Agriculture;State Key Laboratory of Veterinary Etiological Biology;Lanzhou Veterinary Research Institute;Chinese Academy of Agricultural Sciences;Lanzhou;Gansu;730046;China |
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| Abstract: | Currently,inactivated vaccines are still the main vaccines in FMD control programmes.Development of inactivated vaccine against foot and mouth disease is of great realistic significance.The methods are also enriched and improved continuously.The article reviewed the advanced studies on the important steps to develop FMD inactivated vaccines,including the selection of vaccine strains,multiplication,inactivation,purification,concentration of viruses,vaccine formulation and quality control.Selection of vaccine... |
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| Keywords: | Foot-and-mouth disease inactivated vaccine development quality control performance |
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