| 5-硝基水杨醛双缩二氨基硫脲Schiff碱的合成·表征与抑菌活性研究 |
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| 引用本文： | 李琳,尹文华,董风英.5-硝基水杨醛双缩二氨基硫脲Schiff碱的合成·表征与抑菌活性研究[J].宁夏农林科技,2012,53(4):88-89. |
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| 作者姓名： | 李琳 尹文华 董风英 |
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| 作者单位： | 1. 青岛农业大学化学与药学院,山东青岛,266109
2. 青岛市海泊河污水处理厂,山东青岛,266021 |
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| 摘 要： | 目的]合成对称的5-硝基水杨醛双缩二氨基硫脲Shiff碱,并测试其抑菌活性。方法]目标化合物经红外、元素、核磁、质谱确证其化学结构,并用管碟法测试其抑菌活性。结果]4种不同浓度对2种细菌均有一定程度的抑菌效果,但对革兰氏阳性金黄色葡萄球菌的抑菌效果优于大肠杆菌。结论]该新化合物对革兰氏阳性金黄色葡萄球菌有较好的抑制效果。
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| 关 键 词： | 1 3-二氨基硫脲 5-硝基水杨醛 Shiff碱 抑菌活性 |
Study on Synthesis Characterization and Antibacterial Activities of Schiff Base Condensed from 5-nitrosalicylaldehyde and Thiocarbohydrazide |
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| Institution: | LI Lin et al(College of Chemistry and Pharmaceutical Sciences,Qingdao Agricultural University,Qingdao,Shandong 266109) |
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| Abstract: | Objective] The aim was to obtain Bis-Schiff base condensed from 5-nitrosalicylaldehyde and thiocarbohydrazide,and test its antibacterial activities.Method] Its structure was characterized by elemental analysis,IR,MS,and 1H-NMR.At the same time the antibacterial activities of the compound were tested by cylinder-plate method.Result] The results showed that four different concentration had a certain antibacterial effect to two bacteria,and had better activities against Staphylococcus aureus than E.coli.Conclusion] The new Schiff base had better activities against Staphylococcus aureus. |
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| Keywords: | 3-nitrosalicylaldehyde 5-nitrosalicylaldehyde Schiff base Antibacterial activities |
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