| 披针叶黄华碱对小鼠半数致死量的测定 |
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| 引用本文： | 李勇,李生虎,张永康,何生虎.披针叶黄华碱对小鼠半数致死量的测定[J].中兽医医药杂志,2013(6):56-58. |
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| 作者姓名： | 李勇 李生虎 张永康 何生虎 |
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| 作者单位： | [1]宁夏职业技术学院生命科学技术系,宁夏银川750021 [2]宁夏大学,宁夏银川750021 |
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| 基金项目： | 宁夏职业技术学院科研发展基金资助（课题批准号：XJ201307） |
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| 摘 要： | 目的：以小鼠为试验动物,对披针叶黄华碱的毒性进行研究,测定其生物碱组分的半数致死量.方法：用体积分数为95％的乙醇结合超声波对披针叶黄华植物进行提取,以小鼠为试验动物,研究拨针叶黄华碱氯仿萃取组分的毒性.结果：通过试验测得披针叶黄华碱萃取组分的半数致死量为127.04 mg/kg,95％可信限为115.41-139.72 mg/kg.结论：试验结果与报道数据差异较大,可能与试验方法、萃取药液的实际浓度等因素有关.
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| 关 键 词： | 披针叶黄华碱 小鼠 半数致死量 |
LD50 determination of Thermopsis lanceolate alkaloid in mice |
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| LI Yong,LI Sheng-hu,ZHANG Yong-kang,HE Sheng-hu.LD50 determination of Thermopsis lanceolate alkaloid in mice[J].Journal of Traditional Chinese Veterinary Medicine,2013(6):56-58. |
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| Authors: | LI Yong LI Sheng-hu ZHANG Yong-kang HE Sheng-hu |
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| Institution: | 1.Department of Life Science, Ningxia Polytechnic, Yinehuan Ningxia 750021 ; 2.Ningxia University, Yinchuan Ningxia750021, China) |
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| Abstract: | Objective： To study the toxicity of Thermopsis lanceol~e alkaloid and determine its half lethal dose （LD50）. Methods： Alkaloids were extracted with chloroform and n-butanol respectively from Thermopsis lanceolate treated by 95% ethanol with combination of ultrasound. Then the toxicities of alkaloids were determined with mice as test animals. Results： LD50 of chloroform extraction component was 127.04 mg/kg with the 95% confidence limit of 115.41-139.72 mg/kg. Conclusion： The results were varied with data reported, which may be related to test method, the concentration of extracted solution of actual and other factors. |
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| Keywords: | alkaloid of Thermopsis Lanceolate mice LD50 |
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