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Epitheliotropic cutaneous lymphoma (mycosis fungoides) in a dog |
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| Authors: | Dong Ha Bhang Ul Soo Choi Min Kyu Kim Eun-Hwa Choi Min-Soo Kang Cheol-Yong Hwang Dae-Yong Kim Hwa Young Youn Chang Woo Lee |
| Institution: | 1Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.;2Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.;3Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea. |
| Abstract: | A seven-year-old castrated male Yorkshire terrier dog was presented for a recurrent skin disease. Erythematous skin during the first visit progressed from multiple plaques to patch lesions and exudative erosion in the oral mucosa membrane. Biopsy samples were taken from erythematous skin and were diagnosed with epitheliotropic T cell cutaneous lymphoma by histopathology and immunochemical stain. In serum chemistry, the dog had a hypercalcemia (15.7 mg/dl) and mild increased alkaline phosphatase (417 U/l). Immunohistochemistry was performed to detect parathyroid hormone-related peptide (PTH-rP) in epitheliotropic cutaneous lymphoma tissues but the neoplastic cells were not labeled with anti-PTH-rP antibodies. The patient was treated with prednisolone and isotretinoin. However, the dog died unexpectedly. |
| Keywords: | dog epitheliotropic cutaneous lymphoma hypercalcemia mycosis fungoides PTH-rP |