Subcutaneous pharmacokinetics and dosage regimen of cefotaxime in buffalo calves (Bubalus bubalis) |
| |
| Authors: | Suresh Kumar Sharma Anil Kumar Srivastava |
| |
| Institution: | 1Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, Ludhiana-141 004, India.;2Faculty of Veterinary Science and Animal Husbandry, Sher-e-Kashmir University of Agriculture Science and Technology (SKUAST), R.S.Pura-181 102, India. |
| |
| Abstract: | The pharmacokinetics and dosage regimen of cefotaxime following its single subcutaneous administration (10 mg/kg) were investigated in buffalo calves. Plasma and urine samples were collected over 10 and 24 h post administration, respectively. Cefotaxime in plasma and urine was estimated by microbiological assay technique using E. coli as test organism. The pharmacokinetic profiles fitted one-compartment open model. The peak plasma levels of cefotaxime were 6.48 ± 0.52 µg/ml at 30 min and the drug was detected upto 10 h. The absorption half-life and elimination half-life were 0.173 ± 0.033 h and 1.77 ± 0.02 h, respectively. The apparent volume of distribution and total body clearance were 1.17 ± 0.10 l/kg and 0.45 ± 0.03 l/kg/h, respectively. The urinary excretion of cefotaxime in 24 h, was 5.36 ± 1.19 percent of total administrated dose. A satisfactory subcutaneous dosage regimen for cefotaxime in buffalo calves would be 13 mg/kg repeated at 12 h intervals. |
| |
| Keywords: | buffalo calf cefotaxime dosage regimen pharmacokinetics |
|
|
