| 石榴皮多酚对痤疮丙酸杆菌体外抑菌活性的研究 |
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| 作者姓名： | 张晓玲 朱明芳 杨 柳 胡 彬 谢 遥 |
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| 作者单位： | 1.湖南中医药大学，湖南 长沙 410208；2.湖南中医药大学第二附属医院，湖南 长沙 410005 |
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| 基金项目： | 湖南省中医药科研计划项目（2012109）；湖南省中医药科研计划重点项目（201425）；湖南省发改委（湘财建指[2014]177号）。 |
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| 摘 要： | 目的 研究石榴皮多酚对痤疮主要致病菌——痤疮丙酸杆菌的抑制作用。方法 首先用生长抑制试验(牛津杯法)确定石榴皮多酚醇提物对痤疮丙酸杆菌是否存在抑制作用，然后通过药基琼脂稀释法观察它对痤疮丙酸杆菌的MIC来评价该药物对所测细菌的抑制作用。结果 石榴皮多酚醇提物500、300、100 mg/mL对痤疮丙酸杆菌ATCC11827具有较强的抑菌活性，其对痤疮丙酸杆菌的MIC为20 mg/mL。结论 石榴皮多酚醇提物在体外具有明确的抑制痤疮丙酸杆菌活性的作用。
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| 关 键 词： | 石榴皮多酚 痤疮丙酸杆菌 抑菌 痤疮 牛津杯法 琼脂稀释法 |
Antibacterial Effect of Pomegranate Peel Polyphenols against Propionibacterium acnes in Vitro |
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| Authors: | Xiao-Ling Zhang Ming-Fang Zhu Liu Yang Bin Hu Yao Xie |
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| Institution: | 1. Hunan university of Chinese medicine, Changsha, Hunan 410007, China;2. The Second Affiliated Hospital of Hunan University of Chinese medicine, Changsha, Hunan 410005, China |
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| Abstract: | Objective To study the inhibiting effect of pomegranate peel polyphenols on Propionibacterium acnes, the main pathogenic bacteria of acne. Methods First growth inhibition test (Oxford cup method) are used to determine the inhibiting effect of pomegranate peel polyphenols alcohol extract inhibition on P. acne. Then the inhibiting effect of drug to the test bacteria inhibition was evaluated through in vitro agar dilution method for observing the MIC of P. acne. Results Pomegranate peel polyphenols alcohol extract (500, 300, 100 mg/mL) showed strong antibacterial activity on P. acne ATCC11827, and its MTC to P. acne was for 20 mg/mL. Conclusion Pomegranate peel polyphenols alcohol shows a clear role in inhibiting the activity on P. acne in vitro. |
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| Keywords: | pomegranate peel polyphenols Propionibacterium acnes bacteriostasis acne Oxford cup method agar dilution method |
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