Stopped-flow studies of the inhibition of acetylcholinesterase by organophosphates in the presence of substrate |
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| Authors: | Geoffrey J Hart Richard D O&#x;Brien |
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| Institution: | Section of Neurobiology and Behavior, Cornell University, Ithaca, New York 14850 USA |
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| Abstract: | The stopped-flow technique has been applied to the determination of dissociation, phosphorylation, and bimolecular reaction constants for the inhibition of acetylcholinesterase by a potent organophosphate in the presence of a chromogenic substrate. The advantages of the method for inhibition studies are compared with those of an earlier spectrophotometric technique. |
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