Pharmacokinetics of Enrofloxacin and Its Metabolite Ciprofloxacin after Intramuscular Administration of Enrofloxacin in Goats |
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| Authors: | Rao GS Ramesh S Ahmad AH Tripathi HC Sharma LD Malik JK |
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| Institution: | (1) Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, 243 122 (U.P.), India;(2) Department of Pharmacology and Toxicology, College of Veterinary Sciences, GBPUA&T, Pantnagar, 263 145 (U.P.), India |
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| Abstract: | The pharmacokinetics of enrofloxacin and its active metabolite ciprofloxacin were investigated in goats after a single intramuscular administration of enrofloxacin at 2.5 mg/kg body weight. The plasma concentrations of enrofloxacin and ciprofloxacin were determined simultaneously by a HPLC method. The peak concentrations (C
max) of enrofloxacin (1.13  g/ml) and ciprofloxacin (0.24 g/ml) were observed at 0.8 and 1.2 h, respectively. The elimination half-life (t
1/2 ), volume of distribution (V
d(area)), total body clearance (ClB) and mean residence time (MRT) of enrofloxacin were 0.74 h, 1.42 L/kg, 1329 ml/h per kg and 1.54 h, respectively. The t
1/2, area under the plasma concentration–time curve (AUC) and the MRT of ciprofloxacin were 1.38 h, 0.74 g h/ml and 2.73 h, respectively. The metabolic conversion of enrofloxacin to ciprofloxacin was appreciable (36%) and the sum of the plasma concentrations of enrofloxacin and ciprofloxacin was maintained at or above 0.1 g/ml for up to 4 h. Enrofloxacin appears to be useful for the treatment of goat diseases associated with pathogens sensitive to this drug. |
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| Keywords: | ciprofloxacin dosage enrofloxacin goats pharmacokinetics plasma concentrations |
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