Efficacy of phosphomycin in the control of Escherichia coli infection of broiler chickens |
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| Authors: | A Fernandez C Lara R Puyuelo J Gomez JJ Ramos A Loste MC Marca MT Verde |
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| Institution: | Department of Animal Pathology, Veterinary Faculty, Miguel Servet, 177, 50013-Zaragoza, Spain |
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| Abstract: | Seventy-five 25-day-old broilers were divided into three groups: group I unmedicated and challenged with E coli 078:K80; group F infected and treated with 150 ppm of phosphomycin in their drinking water, and group C acted as a control. Their weights, feed intake, clinical signs, macroscopic lesions, E coli reisolation, and serum biochemistry were compared. Group F showed fewer symptoms and gross lesions than those from group I while the average daily gain, bodyweight, and feed intake were similar to the control group. E coli was reisolated in 32 per cent of the livers and spleens from group I, compared with 4 per cent of liver and 8 per cent of spleens from group F. There was an increase in the levels of total protein and globulins in group I but not in group F. These results provide evidence of the therapeutic efficacy of phosphomycin in the control of an experimental E coli infection in broiler chickens. |
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