Overexpression of SSTR2 inhibits growth of SSTR2-positive tumors via multiple signaling pathways |
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| Authors: | XIAO Xiao-ping LI Yue-qin XU Bin LI Hong-jian ZHANG Xin ZHOU Tian-hong ZOU Yi |
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| Institution: | Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. E-mail: zouyi_2002@yahoo.com.cn |
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| Abstract: | AIM: To study the anti-proliferation effect of overexpressed SSTR2 in experimental cancer with different profiles of endogenous SSTRs expressions and the possible signaling pathways involved. METHODS: In the first experiment, the growth of the tumor xenografts of the inoculated capan-2 cells and A549 cells overexpressing SSTR2 or LacZ was investigated in nude mice. In the second experiment, the adenoviral vector expressing SSTR2 were introduced into experimental capan-2 xenografts by intratumoral injection. The growth inhibition of these experiment tumors was observed and the potential influences on different signaling pathways were analyzed by immunoassays. RESULTS: Overexpression of SSTR2 inhibited the growth of tumors with different profiles of endogenous SSTRs, including experimental capan-2 xenografts that had endogenous SSTR2 expression. Overexpression significantly affected a number of components in apoptotic pathway, MAPK pathway and angiogenesis. CONCLUSION: SSTR2 is a promising candidate for gene therapy in a wide spectrum of cancers. |
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