Effects of glucocorticoid inhalation on the levels of CD4+CD25+ regulatory T cells in peripheral blood of asthmatic children |
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| Authors: | HUANG Hua-rong LIU Tian-tian WEI Jing TAN Wei-ping WU Bao-jing MAI Xian-di |
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| Institution: | 1.Department of Pediatrics, 3Medical Research Center, The Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China;2.Department of Pediatrics, The Second Affiliated Hospital of Guangzhou Medical College, Guangzhou 510182, China. E-mail: hhrvivi@21cn.com |
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| Abstract: | AIM: To investigate the effect of glucocorticoid inhalation on the levels of CD4+CD25+ regulatory T cells in peripheral blood of asthmatic children. METHODS: Glucocorticoid inhalator was inhaled by 70 children with attack asthma. The levels of CD4+CD25+Tr in peripheral blood of asthmatic children were tested by flow cytometry (FCM). RESULTS: The CD4+CD25+Tr levels in peripheral blood of asthmatic children were (5.62%±1.29%) and (7.05%±1.61%) before and after of regulated glucocorticoid inhalation, respectively (P<0.01). The Tr levels were (7.56%±1.88%), (7.09%±1.23%) and (6.11%±1.96%) in the complete control group, part control group and poor control group, respectively (P<0.05). The Tr level in formal treatment group (7.05%±1.61%) was higher than that in irregular treatment group (5.91%±1.76%), P<0.01. CONCLUSION: The level of CD4+CD25+Tr is remarkable increased by regulated glucocorticoid inhalation, and the level of Tr can reflect the effects of glucocorticoid inhalation. |
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