Expression of EPCAM,CD44 and CD24 in gastric cancer tissues and its clinical significance |
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| Authors: | YANG Shi-bin XIAO Long-bin XU Feng-feng WU Wen-hui LI Shou-zhi LI Ming-zhe |
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| Institution: | Department of General Surgery, Huangpu Hospital, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510700, China |
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| Abstract: | AIM: To evaluate the relationship between epithelial cell adhesion molecule (EPCAM)/cluster of differentiation 44 (CD44)/cluster of differentiation 24 (CD24) expression and the clinicopathological characteristics/prognosis in 95 gastric cancer patients. METHODS: The expression levels of EPCAM, CD44 and CD24 were detected using the two-step method of immunohistochemistry in 95 gastric cancer patients who underwent surgical excision and were pathologically diagnosed as gastric cancer. RESULTS: There were 56 EPCAM-positive patients (58.95%), 41 CD44-positive patients (43.16%) and 56 CD24-positive patients (58.95%). Thirty patients were both EPCAM and CD44 positive (31.58%), 45 patients were both EPCAM and CD24 positive (47.37%), 32 patients were both CD44 and CD24 positive (33.68%), and 25 patients were EPCAM, CD44 and CD24 positive (26.32%). EPCAM expression was correlated with age, depth of tumor infiltration and WHO histological classification. CD44 expression was correlated with BORRMANN and WHO histological classification as well as CEA value. CD24 expression was correlated with the depth of infiltration, location of the tumor, WHO histological classification and viscera invasion. All positive expression of EPCAM, CD44 and CD24 was correlated with the depth of infiltration, location of the tumor and WHO histological classification (P<0.05). The difference of survival rate between EPCAM positive group and negative group was observed, and the CD44 positive group and negative group had the same result (P<0.05 and P<0.01, respectively). The difference of survival rate between EPCAM+CD44+CD24+ group and EPCAM-CD44-CD24- group was statistically significant (P<0.05). The difference of survival rate between EPCAM-CD44+CD24+ group and EPCAM-CD44-CD24- group was also significant (P<0.05). CONCLUSION: The positive rates of EPCAM, CD44 and CD24 expression are high in gastric cancer tissues and these 3 proteins can be used as primary screening targets. |
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| Keywords: | Epithelial cell adhesion molecule CD44 CD24 Stomach neoplasms |
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