Effect of Liang Xue Huo Xue capsules on mouse psoriasis-like lesions induced by imiquimod |
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| Authors: | DI Ting-ting ZHAO Jing-xia WANG Yan LIU Xin LIANG Dai-ying LI Ping |
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| Institution: | Department of Pathophysiology, Beijing Institute of Traditional Chinese Medicine, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing 100010, China |
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| Abstract: | AIM: To observe the effects of Liang Xue Huo Xue (LXHX) capsules on mouse psoriasis-like lesions induced by imiquimod (IMQ). METHODS: BALB/c female mice (n=48) were randomly divided into 6 groups: normal group, model group, LXHX capsules groups with high, medium or low doses, and glycosides of Tripterygium wilfordii (GTW) group. On day 8, skin lesions were determined by pathological examination. The lesions were evaluated according to the psoriasis area and severity index (PASI). The histology and epidermal thicknesses were observed under light microscope. The expression of proliferating cell nuclear antigen (PCNA) was detected by immunohistochemical staining. Meanwhile, the positive expression of CD3, CD11c, F4/80, CD31 and Gr-1 was counted by immunohistochemical staining. RESULTS: Compared with model group, the cutaneous symptoms in LXHX capsules groups were alleviated, with PASI scores decreased, epidermal parakeratosis and epidermal over-proliferation relived, the numbers of dermal T lymphocytes, dendritic cells, macrophages, neutrophils and monocytes reduced significantly. CONCLUSION: LXHX capsules improve imiquimod-induced mouse psoriasis-like lesions by inhibiting over-proliferation of keratinocytes, parakeratosis, inflammatory infiltration and angiogenisis. |
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| Keywords: | Psoriasis Imiquimod Liang Xue Huo Xue capsules |
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