Studies on antimicrobial activity for multidrug resistance strain by using phenyl pyrazolones substituted 3-(4-aminophenyl)-2-phenylquinazolin-4(3H)-one derivatives in vitro condition and their dyeing performance |
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| Authors: | Nikhil Parekh Kalpana Maheria |
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| Institution: | 1.Applied Chemistry Department,S. V. National Institute of Technology,Gujarat,India |
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| Abstract: | Heterocyclic monoazo quinazolinone based azo dyes derived by the diazotization of 3-(4-aminophenyl)-2-phenylquinazolin-4(3H)-one
with various phenyl pyrazolones based coupling components. All the heterocyclic azo dyes have been characterized by their
percentage yield, UV-VIS spectroscopy, elemental analysis, IR spectroscopy, 1H NMR spectroscopy, and dyeing performance on silk, wool, nylon, and polyester fibers. All the dyes gave moderate to excellent
fastness properties on each fiber. The main focus was to synthesize heterocyclic monoazo dyes that give good dyeing property
along with pharmacological activity (anti bacterial and antifungal). Therefore, the synthesized compounds were examined for
their antimicrobial activity at various concentrations using well-known Kirby-Bauer disk diffusion method. |
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