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Interleukin 1, a mediator of immunoadjuvant peptidoglycans |
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| Authors: | M Guenounou F Vacheron C Nauciel |
| Institution: | 1 Laboratoire de Microbiologie, UER de Médecine Paris Ouest, 92380, Garches, France 2 CNRS-ERA No. 396, Université Paris-Sud, 92290, Chatenay-Malabry, France 3 Immumochimie des Protéines, Institut Pasteur, France |
| Abstract: | Bacterial peptidoglycans and the synthetic analog muramyl dipeptide possess various immunomodulating properties (adjuvant effect, increase of resistance to infectious agents and to tumor growth). They are able to induce B cell activation and to stimulate macrophages to produce monokines such as Interleukin 1 (IL 1). IL 1 plays an essential role in immune response. It promotes thymocytes maturation and Interleukin 2 secretion by antigen sensitive T cells, which in turn triggers regulatory T cells. Moreover, it is involved in the proliferation and differentiation of B cells. There is a correlation between the immunoenhancing effect of PG of a definite structure and their ability to induce IL 1 secretion. Non-adjuvant PG were inactive. This suggests that one of the major mechanisms of action of adjuvant PG could be the stimulation of IL 1 synthesis. |
| Keywords: | interleukin 1 macrophage bacterial peptidoglycan muramyl dipeptide immunomodulationAuthor Keywords: interleukine 1 macrophage peptidoglycane bactérien immunomodulation |
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